Cuban and Virgin Island-Inspired Family Restaurant Coming to Orlando

Don Pepe’s to replace a medical equipment depot.

Ross McWaters
By Ross McWaters Add a Comment
Photo: Google Earth Pro

Don Pepe’s Owner Iris Santiago is drawing on her experience operating restaurants in the Virgin Islands to bring Orlando a full-service Cuban and Virgin Island steakhouse. This is her first restaurant in the continental United States. 

Santiago will make room for her new concept by utilizing the space she ran a former business in.

The restaurant will appear at 11240 S Orange Blossom Trail, where Medical Express Depot used to operate. According to Santiago, during the pandemic, it made more sense to close down the medical equipment business and open a family-owned restaurant, which had been a dream of theirs for 7 years.

They are currently remodeling the space to accommodate the Don Pepe’s. Santiago doesn’t have a firm opening date, but she is hoping for “late February.” 

The location will be in a plaza with other restaurants offering various cuisines, such as El Tenampa Mexican Restaurant and Bakery, Ají Ceviche Bar and Bahama Buck’s Shaved Ice. 

A plan review filing with the state was approved with provisions last month. 

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